Gene information
Official symbol NFKB1
Official full name nuclear factor kappa B subunit 1
Gene type protein-coding gene
Chromosome4q24
Alias symbolKBF1; p105; NFKB-p50; p50; NF-kappaB; NFkappaB; NF-kB1
Gene familyAnkyrin repeat domain containing; NF-kappa B complex subunits; IPT domain containing
Resources
Entrez Gene 4790
HGNC HGNC:7794
Ensembl ENSG00000109320
Vega OTTHUMG00000161080
UCSC uc011cep.2
GO terms: 96 records
GO Description Category LogP Number of genes Detail
GO:0000165 MAPK cascade GO Biological Processes -7.43732657 14 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0006109 regulation of carbohydrate metabolic process GO Biological Processes -13.1742479 35 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007254 JNK cascade GO Biological Processes -1.73908250 3 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0010743 regulation of macrophage derived foam cell differentiation GO Biological Processes -20.3455172 15 More
GO:0010744 positive regulation of macrophage derived foam cell differentiation GO Biological Processes -12.0744578 9 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0010883 regulation of lipid storage GO Biological Processes -22.5241589 19 More
GO:0010884 positive regulation of lipid storage GO Biological Processes -7.64826410 7 More
GO:0010894 negative regulation of steroid biosynthetic process GO Biological Processes -4.13020121 7 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019218 regulation of steroid metabolic process GO Biological Processes -14.2494824 17 More
GO:0030111 regulation of Wnt signaling pathway GO Biological Processes -7.94227486 39 More
GO:0030177 positive regulation of Wnt signaling pathway GO Biological Processes -5.04077211 10 More
GO:0030656 regulation of vitamin metabolic process GO Biological Processes -3.47400635 3 More
GO:0031098 stress-activated protein kinase signaling cascade GO Biological Processes -2.08184246 4 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032350 regulation of hormone metabolic process GO Biological Processes -3.18614571 7 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032369 negative regulation of lipid transport GO Biological Processes -16.5715041 21 More
GO:0032371 regulation of sterol transport GO Biological Processes -19.2332049 29 More
GO:0032372 negative regulation of sterol transport GO Biological Processes -11.6691020 14 More
GO:0032374 regulation of cholesterol transport GO Biological Processes -19.2332049 29 More
GO:0032375 negative regulation of cholesterol transport GO Biological Processes -11.6691020 14 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032655 regulation of interleukin-12 production GO Biological Processes -15.9447313 16 More
GO:0032695 negative regulation of interleukin-12 production GO Biological Processes -6.32323278 8 More
GO:0032768 regulation of monooxygenase activity GO Biological Processes -14.2762890 21 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0032881 regulation of polysaccharide metabolic process GO Biological Processes -7.60302561 13 More
GO:0032885 regulation of polysaccharide biosynthetic process GO Biological Processes -7.40593429 12 More
GO:0034612 response to tumor necrosis factor GO Biological Processes -24.4651326 32 More
GO:0034654 nucleobase-containing compound biosynthetic process GO Biological Processes -2.18989332 18 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035094 response to nicotine GO Biological Processes -8.07167727 14 More
GO:0035580 specific granule lumen GO Cellular Components -14.6396218 15 More
GO:0035994 response to muscle stretch GO Biological Processes -4.25041921 7 More
GO:0042581 specific granule GO Cellular Components -15.6202777 22 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043255 regulation of carbohydrate biosynthetic process GO Biological Processes -8.87798147 21 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0045833 negative regulation of lipid metabolic process GO Biological Processes -7.94928400 20 More
GO:0045913 positive regulation of carbohydrate metabolic process GO Biological Processes -10.1978214 20 More
GO:0045939 negative regulation of steroid metabolic process GO Biological Processes -3.80289411 7 More
GO:0046890 regulation of lipid biosynthetic process GO Biological Processes -16.6841590 23 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050810 regulation of steroid biosynthetic process GO Biological Processes -7.92957130 10 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051055 negative regulation of lipid biosynthetic process GO Biological Processes -6.84973913 14 More
GO:0051341 regulation of oxidoreductase activity GO Biological Processes -18.1249013 32 More
GO:0051354 negative regulation of oxidoreductase activity GO Biological Processes -6.94413823 11 More
GO:0051403 stress-activated MAPK cascade GO Biological Processes -2.17536173 4 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0060556 regulation of vitamin D biosynthetic process GO Biological Processes -4.25319477 3 More
GO:0060558 regulation of calcidiol 1-monooxygenase activity GO Biological Processes -8.3287979 5 More
GO:0060828 regulation of canonical Wnt signaling pathway GO Biological Processes -5.69122875 29 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0062014 negative regulation of small molecule metabolic process GO Biological Processes -11.3582124 24 More
GO:0070555 response to interleukin-1 GO Biological Processes -18.9736890 36 More
GO:0070741 response to interleukin-6 GO Biological Processes -9.27147512 9 More
GO:0071214 cellular response to abiotic stimulus GO Biological Processes -11.2775864 23 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071260 cellular response to mechanical stimulus GO Biological Processes -11.7214175 13 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071347 cellular response to interleukin-1 GO Biological Processes -16.1002741 19 More
GO:0071354 cellular response to interleukin-6 GO Biological Processes -8.31494447 8 More
GO:0071356 cellular response to tumor necrosis factor GO Biological Processes -22.5666334 29 More
GO:0071375 cellular response to peptide hormone stimulus GO Biological Processes -15.9961580 44 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071407 cellular response to organic cyclic compound GO Biological Processes -19.6857751 39 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0090263 positive regulation of canonical Wnt signaling pathway GO Biological Processes -2.20870076 11 More
GO:0098586 cellular response to virus GO Biological Processes -6.52248641 17 More
GO:0104004 cellular response to environmental stimulus GO Biological Processes -11.2775864 23 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901653 cellular response to peptide GO Biological Processes -21.5212108 58 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1902930 regulation of alcohol biosynthetic process GO Biological Processes -4.27715369 6 More
GO:1902931 negative regulation of alcohol biosynthetic process GO Biological Processes -4.45456766 4 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905953 negative regulation of lipid localization GO Biological Processes -25.1573575 31 More
GO:1905954 positive regulation of lipid localization GO Biological Processes -22.7388039 24 More
GO:1990776 response to angiotensin GO Biological Processes -9.91352700 13 More
KEGG pathways: 73 records
KEGG Description Category LogP Number of genes Detail
hsa01523 Antifolate resistance KEGG Pathway -5.90548425 6 More
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04024 cAMP signaling pathway KEGG Pathway -7.78464854 30 More
hsa04062 Chemokine signaling pathway KEGG Pathway -9.12263704 17 More
hsa04064 NF-kappa B signaling pathway KEGG Pathway -10.0294934 14 More
hsa04066 HIF-1 signaling pathway KEGG Pathway -20.6790877 23 More
hsa04071 Sphingolipid signaling pathway KEGG Pathway -4.55426967 9 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04210 Apoptosis KEGG Pathway -6.60042966 12 More
hsa04211 Longevity regulating pathway KEGG Pathway -6.96966761 10 More
hsa04218 Cellular senescence KEGG Pathway -5.14633043 11 More
hsa04380 Osteoclast differentiation KEGG Pathway -7.05199617 21 More
hsa04613 Neutrophil extracellular trap formation KEGG Pathway -12.8071279 20 More
hsa04620 Toll-like receptor signaling pathway KEGG Pathway -11.1460554 15 More
hsa04621 NOD-like receptor signaling pathway KEGG Pathway -7.63493695 15 More
hsa04622 RIG-I-like receptor signaling pathway KEGG Pathway -3.50554828 6 More
hsa04623 Cytosolic DNA-sensing pathway KEGG Pathway -5.78243801 8 More
hsa04625 C-type lectin receptor signaling pathway KEGG Pathway -5.36927089 9 More
hsa04657 IL-17 signaling pathway KEGG Pathway -16.8039621 19 More
hsa04658 Th1 and Th2 cell differentiation KEGG Pathway -5.18694144 15 More
hsa04659 Th17 cell differentiation KEGG Pathway -9.80516906 14 More
hsa04660 T cell receptor signaling pathway KEGG Pathway -4.46130434 8 More
hsa04668 TNF signaling pathway KEGG Pathway -16.5384917 20 More
hsa04917 Prolactin signaling pathway KEGG Pathway -3.17844000 10 More
hsa04920 Adipocytokine signaling pathway KEGG Pathway -10.4150431 19 More
hsa04926 Relaxin signaling pathway KEGG Pathway -10.8215200 16 More
hsa04931 Insulin resistance KEGG Pathway -8.40376708 21 More
hsa04932 Non-alcoholic fatty liver disease KEGG Pathway -11.2628136 17 More
hsa04933 AGE-RAGE signaling pathway in diabetic complications KEGG Pathway -25.8646207 26 More
hsa04936 Alcoholic liver disease KEGG Pathway -13.3477535 19 More
hsa05010 Alzheimer disease KEGG Pathway -5.39034067 17 More
hsa05022 Pathways of neurodegeneration - multiple diseases KEGG Pathway -4.18311884 18 More
hsa05030 Cocaine addiction KEGG Pathway -1.78827574 6 More
hsa05120 Epithelial cell signaling in Helicobacter pylori infection KEGG Pathway -1.87202281 4 More
hsa05130 Pathogenic Escherichia coli infection KEGG Pathway -9.84822677 18 More
hsa05131 Shigellosis KEGG Pathway -5.26807538 14 More
hsa05132 Salmonella infection KEGG Pathway -7.42305681 17 More
hsa05133 Pertussis KEGG Pathway -13.2270528 15 More
hsa05134 Legionellosis KEGG Pathway -13.8022551 14 More
hsa05135 Yersinia infection KEGG Pathway -7.02427022 12 More
hsa05140 Leishmaniasis KEGG Pathway -12.4439861 14 More
hsa05142 Chagas disease KEGG Pathway -21.3868632 23 More
hsa05145 Toxoplasmosis KEGG Pathway -13.6215025 17 More
hsa05146 Amoebiasis KEGG Pathway -14.8474637 18 More
hsa05152 Tuberculosis KEGG Pathway -14.5221547 22 More
hsa05160 Hepatitis C KEGG Pathway -4.71256920 10 More
hsa05161 Hepatitis B KEGG Pathway -5.78517620 12 More
hsa05162 Measles KEGG Pathway -4.80674483 10 More
hsa05163 Human cytomegalovirus infection KEGG Pathway -9.77103740 19 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
hsa05165 Human papillomavirus infection KEGG Pathway -8.63301470 40 More
hsa05166 Human T-cell leukemia virus 1 infection KEGG Pathway -5.08552863 13 More
hsa05167 Kaposi sarcoma-associated herpesvirus infection KEGG Pathway -9.05308086 17 More
hsa05168 Herpes simplex virus 1 infection KEGG Pathway -3.99478875 17 More
hsa05169 Epstein-Barr virus infection KEGG Pathway -3.79267986 10 More
hsa05170 Human immunodeficiency virus 1 infection KEGG Pathway -2.98955463 9 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05202 Transcriptional misregulation in cancer KEGG Pathway -9.99536642 18 More
hsa05203 Viral carcinogenesis KEGG Pathway -1.94955729 7 More
hsa05207 Chemical carcinogenesis - receptor activation KEGG Pathway -7.05448873 28 More
hsa05208 Chemical carcinogenesis - reactive oxygen species KEGG Pathway -3.44838603 10 More
hsa05212 Pancreatic cancer KEGG Pathway -2.89550682 10 More
hsa05215 Prostate cancer KEGG Pathway -7.21675759 11 More
hsa05220 Chronic myeloid leukemia KEGG Pathway -2.89550682 10 More
hsa05221 Acute myeloid leukemia KEGG Pathway -2.91912787 5 More
hsa05222 Small cell lung cancer KEGG Pathway -6.83164026 10 More
hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer KEGG Pathway -4.03177682 7 More
hsa05321 Inflammatory bowel disease KEGG Pathway -16.3800424 16 More
hsa05415 Diabetic cardiomyopathy KEGG Pathway -11.4800633 20 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
hsa05418 Fluid shear stress and atherosclerosis KEGG Pathway -23.1665561 27 More
Drug-Gene interaction
view
Related drugs: 90 records
Drug name Interaction type Source PMID View
(+)-epitaxifolin DTC view
(r)-nitrendipine DTC view
(r,s)-indatraline DTC view
(s)-mexiletine DTC view
3r14s-ochratoxin a DTC view
4',7-dimethoxy-5-hydroxygenistein DTC view
6,4'-dimethoxyflavone DTC view
acacetin DTC 25190466 view
andrographolide DTCTdgClinicalTrial 25615020 view
apigenin DTC 25190466 view
artesunate DTC 25074847 view
baclofen DTC view
bardoxolone TdgClinicalTrial view
benzethonium chloride DTC view
benzo(k)fluoranthene DTC view
bortezomib ClearityFoundationClinicalTrial view
chelerythrine DTC view
chelidamic acid DTC view
chembl1405979 DTC view
chembl201325 DTC view
chembl2094789 DTC view
chembl260560 DTC view
chembl275311 DTC view
chembl34730 DTC view
chembl406557 DTC view
chembl408850 DTC view
chembl428789 DTC view
chembl466465 DTC view
chembl502774 DTC view
chembl51697 DTC view
chembl528694 DTC view
chembl578741 DTC view
chembl595227 DTC view
chembl602718 DTC view
chembl605003 DTC view
chembl63329 DTC view
chembl72365 DTC view
chembl84010 DTC view
chembl85826 DTC view
chlorambucil DTC view
chlorpropamide DTC view
chrysoeriol DTC 25190466 view
daph DTC view
dehydroxymethylepoxyquinomicin DTC 18729348 view
dihydrexidine DTC view
diosmetin DTC 25190466 view
disulfiram DTC view
dyrene DTC view
e-flupentixol PharmGKB 27992301 view
epigalocatechin gallate DTC view
fenretinide DTC view
frentizole DTC view
furafylline DTC view
gossypetin DTC 25190466 view
gw7647 DTC view
hydrocortisone DTC view
hydroquinone DTC view
indoprofen DTC view
isorhamnetin DTC 25190466 view
kaempferide DTC 25190466 view
kaempferol DTC 25190466 view
lapachone DTC view
luteolin DTC 25190466 view
ly-294002 DTC view
mitoxantrone DTC view
nifedipine DTC view
nordihydroguaiaretic acid DTC view
parthenolide DTC 25190466 view
pectolinarigenin DTC view
phenamil methanesulfonate DTC view
promethazine hydrochloride DTC view
protriptyline DTC view
quercetagetin DTC 25190466 view
quercetin DTC 25190466 view
resveratrol DTC view
ritanserin DTC view
rutin DTC 25496805 view
sanguinarium DTC view
sb-222200 DTC view
sorbinil DTC 24819954 view
sulfaphenazole DTC view
tamarixetin DTC 25190466 view
tetrabromobenzotriazole DTC view
thalidomide antagonist TdgClinicalTrialTEND 1175235215723633 view
triamcinolone DTC view
tryptamine DTC view
tyrphostin 1 DTC view
tyrphostin 23 DTC view
tyrphostin 47 DTC view
tyrphostin ag-1478 DTC view
Related studies: 3 records
Molecular factor Omics type Application Objective MI type Reference
NM_003998.4:c.-94delATTG genomics myocardial infarction[diagnosis] myocardial infarction Boccardi V et al. Nutr Metab Cardiovasc Dis. 2011
nuclear factor NF-kappa-B p105 subunit proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Liao XX et al. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008
NG_050628.1:g.4670ATTG[1] genomics myocardial infarction[diagnosis] myocardial infarction Luo JY et al. Sci Rep. 2020
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